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M94A2429.TXT
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Document 2429
DOCN M94A2429
TI Risk of HIV-related symptoms in 40 sets of twins: a population-based
analysis.
DT 9412
AU Fanning T; Krasinski K; Chiarella J; Turner BJ; New York State (NYS)
Dept. of Social Services, Albany.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):306 (abstract no. PC0153). Unique
Identifier : AIDSLINE ICA10/94370146
AB OBJECTIVE: To determine risk factors for HIV-related symptoms among
twins. METHODS: A longitudinal claims data base for NYS
Medicaid-enrolled, HIV-infected parturients in 1985-90 was reviewed and
those delivering twins were analyzed. For twins with matched vital
statistics, we examined longitudinal histories in Medicaid claims files
for an AIDS-defining infection and/or the diagnosis of HIV at > 15 mos.
(likely HIV) or > or = serious infection (e.g., pneumonia) and HIV at <
or = 15 mos. (suspect HIV). Other twins were considered HIV unlikely.
RESULTS: Of 2,823 deliveries to 2,349 women in 1985-90, we identified 60
sets of twins, of whom 40 had vital statistics data. Mean follow-up was
36 mos. (s.d. 20). Overall 7/40 sets (17.5%) had HIV (likely or suspect)
with 5 concordant and 2 discordant (P = .4795 for discordance by
McNemar's test). Of discordant sets, one case each was first-born and
second-born and one set was delivered by C-section. Of 18 C-sections, 5
sets (28%) had HIV compared to 2 of 20 (10%) vaginal deliveries (P = .13
by Fisher's Exact test). One woman with AIDS had a set with both twins
dying of AIDS infections but the twins of the other 10 women with AIDS
were HIV unlikely. Five HIV sets were born to 23 drug users (22%)
compared to 2/17 sets (12%) of non-drug users. Of 28 women with prenatal
care data, 8 had adequate care and 1/8 sets had HIV (12%), compared to
5/20 sets of 20 women with inadequate care (25%). No women used AZT in
pregnancy. CONCLUSION: HIV discordance was uncommon and bidirectional in
these population-based data. Indications for C-section were not
available but no protective effect was observed. Although HIV infections
appeared more frequent among infants of women using drugs or infants of
women with little prenatal care, significance was not achieved in these
data.
DE *Diseases in Twins Female Follow-Up Studies Human HIV
Infections/CONGENITAL/DRUG THERAPY/*TRANSMISSION Infant, Newborn
Longitudinal Studies Pregnancy *Pregnancy Complications,
Infectious/DRUG THERAPY Risk Factors MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).